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  • Pseudomonas aeruginosa turns its environment blue by producing pyocyanin, a redox-active metabolite. Oxygen keeps it bright blue, but when oxygen runs low, the bacteria reduce it and the color fades
  • Pseudomonas aeruginosa (orange) colonizing the mucus layer (green) at the surface of airway organoids (magenta)

Selected

PUBLICATIONS

Meirelles, Persat (2025). Decoding host-microbe interactions with engineered human organoids. EMBO J 44:1569-1573 (https://doi.org/10.1038/s44318-025-00387-3)

Meirelles, Vayena, Debache, Schmidt, Rossy, Distler, Hatzimanikatis, Persat (2024). Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infections. Nat Microbiol 9:3284-3303 (https://doi.org/10.1038/s41564-024-01842-3)

Meirelles, Newman (2022). Phenazines and toxoflavin act as interspecies modulators of resilience to diverse antibiotics. Mol Microbiol 117:1384–1404 (https://doi.org/10.1111/mmi.14915)

Perry*, Meirelles*, Newman (2022). From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance. Nat Rev Microbiol 20(3): 129–142
(https://doi.org/10.1038/s41579-021-00620-w)

Meirelles*, Perry*, Bergkessel, Newman (2021). Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics. PLoS Biology 19(3): e3001093
(https://doi.org/10.1371/journal.pbio.3001093)

Meirelles, Newman (2018). Both toxic and beneficial effects of pyocyanin contribute to the lifecycle of Pseudomonas aeruginosa. Mol Microbiol 110: 995-1010
(https://doi.org/10.1111/mmi.14132)

*= co-first authors

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